Yes, synthetic urine does contain creatine. Creatine is a compound made up of three amino acids that is naturally found in the body and can be supplied through dietary sources. Synthetic urine mimics natural urine composition, so it contains many of the same components and electrolytes present in human urine, including creatinine. Creatinine levels in synthetic urine are usually about half as high as those found in normal human urine samples. This is because synthetic urines are typically designed to match average creatinine levels for adults, rather than reflecting an individual’s exact creatinine level.